盧山，男，博士，南京大學(xué)生命科學(xué)學(xué)院教授、黨委書記，美國科學(xué)進(jìn)步協(xié)會會員，美國植物生物學(xué)家學(xué)會會員，中國海洋湖沼學(xué)會會員，中國藻類學(xué)會副理事長，美國能源部聯(lián)合基因組研究所協(xié)作網(wǎng)指導(dǎo)委員會成員。在國內(nèi)外多所生物系研究院進(jìn)行科學(xué)研究。主要研究方向是植物學(xué)、分子生物學(xué)。

學(xué)習(xí)經(jīng)歷

1984—1987 銅陵三中

1987-1991 南京大學(xué)生物學(xué)系，本科

1991-1994 南京大學(xué)生物學(xué)系，碩士研究生

1994-1997 南京大學(xué)生物學(xué)系，博士研究生

工作經(jīng)歷

2007- 南京大學(xué)生命科學(xué)學(xué)院 教授

2006-2007 南京大學(xué)生命科學(xué)學(xué)院 副教授

2002-2006 Cornell University (US Plant Soil& Nutrition Laboratory) （美國），博士后

2001-2002 Max-Planck Institute for ChemicalEcology (德國)，博士后

1998-2001 中科院上海植物生理研究所植物分子遺傳國家重點實驗室，博士后

1998-1998 University of Connecticut atStamford （美國），訪問學(xué)者

1997-1998 中國科學(xué)院海洋研究所實驗海洋生物學(xué)開放實驗室，博士后 [1]

學(xué)術(shù)兼職

American Association for the Advancement of Science: 會員 (2003-)

American Society of Plant Biologists: 會員 (2003-)

中國藻類學(xué)會: 副理事長 (2007-)

Community Sequencing Program (Porphyra purpurea) of the US DOE Joint Genome Institute: Member of the Steering Committee of the Research Coordination Networks (2007-) 

研究方向

1.類胡蘿卜素的代謝及其調(diào)控機(jī)制;

2.與質(zhì)體發(fā)育相關(guān)的轉(zhuǎn)錄因子及其功能調(diào)控;

3.植物進(jìn)化早期的類胡蘿卜素代謝過程。

研究項目

1. 盧山. 2007. 類胡蘿卜素及類黃酮化合物代謝與調(diào)控研究. 國家重點基礎(chǔ)研究發(fā)展計劃（973）. 課題負(fù)責(zé)人.

2. 盧山. 2007. 新基因or調(diào)節(jié)有色體形成的機(jī)理. 國家自然科學(xué)基金. 課題負(fù)責(zé)人.

3. 盧山. 2006. or基因?qū)�質(zhì)體發(fā)育和胡蘿卜素積累的調(diào)控.上海市教育委員會重點科研項目. 課題負(fù)責(zé)人.

4. 陳曉亞. 2001. 棉酚、青蒿素生物合成途徑及調(diào)控的研究. 國家自然科學(xué)基金重點項目

5. 費修綆. 1998. 紫菜種苗工程. 國家自然科學(xué)基金.

6. 盧山. 1998. 海藻種質(zhì)鑒定和育種的分子生物學(xué)技術(shù). 海洋863子課題. 負(fù)責(zé)人.

7. 盧山. 1992.Systematic study of Phyllostachys Sieb. et Zucc. in China. The Linnean Societyof London. Side Foundation. 課題負(fù)責(zé)人.

科研成果

論文

1. Huang X-Q, Zhao L, Rui J-D, Zhou C-F, Zhuang Z, Lu S*. 2017. At5g19540 Encodes a Novel Protein That Affects Pigment Metabolism and Chloroplast Development in Arabidopsis thaliana. Frontiers in Plant Science 8: 2140

2. Zhou F, Wang C-Y, Gutensohn M, Jiang L, Zhang P, Zhang D, Dudareva N, Lu S*. 2017. A recruiting protein of geranylgeranyl diphosphate synthase controls metabolic flux toward chlorophyll biosynthesis in rice. PNAS 114: 6860-6865.

3. Cao T-J, Huang X-Q, Qu Y-Y, Zhuang Z, Deng Y-Y*, Lu S*. 2017. Cloning and functional characterization of a lycopene β-cyclase from macrophytic red alga Bangia fuscopurpurea. Marine Drugs 15: 116.

4. Cheng Y, Shan Z, Zhou J, Bu Y, Li P*, Lu S*. 2017. Effects of 4-nonylphenol in drinking water on the reproductive capacity of Japanese quails (Coturnix japonica). Chemosphere 175: 219-227

5. Wang Y-W, Chen S-M, Wang W-J, Huang X-Q, Zhou C-F, Zhuang Z, Lu S*. 2016. The DnaJ-like zinc finger domain protein PSA2 affects light acclimation and chloroplast development in Arabidiopsis thaliana. Frontiers in Plant Science 7: 360.

6. Sun T-H, Zhou F, Liu C-J, Zhuang Z, Lu S*. 2015. The DnaJ-like zinc finger domain protein ORANGE localizes to the nucleus in etiolated cotyledons of Arabidopsis thaliana. Protoplasma 253: 1599-1604.

7. Zhou F, Sun T-H, Zhao L, Pan X-W, Lu S*. 2015. The bZIP transcription factor HY5 interacts with the promoter of the monoterpene synthase gene QH6 in modulating its rhythmic expression. Frontiers in Plant Science 6: 304

8. Yang L-E, Huang X-Q, Lu Q-Q, Zhu J-Y, Lu S*. 2015. Cloning and characterization of the geranylgeranyl diphosphate synthase (GGPS) responsible for carotenoid biosynthesis in Pyropia umbilicalis. Journal of Applied Phycology 28: 671-678

9. Nisar N, Li L, Lu S, Khin NC, Pogson BJ*. 2015. Carotenoid metabolism in plants. Molecular Plant 8: 68-82

10. Zhang W-G, Liu M, Zhang P-L, Yu F-G, Lu S, Li P-F*, Zhou J-Y. 2014. Effects of Paraquat on photosynthetic pigments, antioxidant enzymes, and gene expression in Chlorella pyrenoidosa under mixotrophic compared with autotrophic conditions. Archives Of Environmental Contamination And Toxicology 67: 593-600

11. Zhang W-G, Zhang P-L, Sun H, Chen MZ, Lu S, Li PF*. 2014. Effects of various organic carbon sources on the growth and biochemical composition of Chlorella pyrenoidosa. Bioresource Technology 173: 52-58

12. Yang L-E, Huang X-Q, Hang Y, Deng Y-Y, Lu Q-Q, Lu S*. 2014. The P450-type carotene hydroxylase PuCHY1 from Porphyra suggests the evolution of carotenoid metabolism in red algae. Journal of Integrative Plant Biology 56: 902-915.

13. Xie X, Gu W, Gao S, Lu S, Li J, Pang G, Wang G, Shen S. 2013. Alternative electron transports participate in the maintenance of violaxanthin de-epoxidase activity of Ulva sp. under low irradiance. PLoS ONE 8: e78211.

14. Li L*, Yang Y, Xu Q, Owsiany K, Welsch R, Chitchumroonchokchai C, Lu S, van Eck J, Deng XX, Faila M, Thannjaiser T. 2012. The Or gene enhances carotenoid accumulation and stability during post-harvest storage of potato tubers. Molecular Plant 5: 339-352.

15. Chan CX, Blouin N, Zhuang YY, Zaeuner S, Prochnik S, Lindquist E, Lin SJ, Benning C, Lohr M, Yarish C, Gantt E, Grossman A, Lu S, Mueller K, Stiller, JW, Brawley, SH, Bhattacharya D*. 2012. Porphyra (Bangiophyceae) transcriptomes provide insights into red algal development and metabolism. Journal of Phycology 48: 1328-1342.

16. Yang L-E, Jin Q-P, Xiao Y, Xu P, Lu S*. 2013. Improved methods for basic molecular manipulation of the red alga Porphyra umbilicalis (Rhodophyta: Bangiales). Journal of Applied Phycology 25: 245-252.

17. Li JL, Chen QQ, Jin QP, Gao J, Zhao PJ, Lu S, Zeng Y*. 2012. IeCPS2 is potentially involved in the biosynthesis of pharmacologically active Isodon diterpenoids rather than gibberellin. Phytochemistry 76: 32-39.

18. Lu S*, Yarish C. 2011. Interaction of photoperiod and temperature in the development of conchocelis of Porphyra purpurea (Rhodophyta: Bangiales). Journal of Applied Phycology 23: 89-96.

19. Zhou XJ, Sun TH, Wang N, Ling HQ, Lu S, Li L*. 2011. The cauliflower Orange gene enhances petiole elongation by suppressing expression of eukaryotic release factor 1. New Phytologist 190: 89-100.

20. Sun T-H, Liu C-Q, Hui Y-Y, Wu W-K, Zhou Z-G, Lu S*.2010. Coordinated regulation of gene expression for carotenoid metabolism in Chlamydomonas reinhardtii. Journal of Integrative Plant Biology 52: 868-878.

21. Lu S*. 2010. Plant specialized metabolism: the easy and the hard. Journal of Integrative Plant Biology 52: 854-855.

22. Yang CQ, Lu S, Mao YB, Wang LJ, Chen XY*. 2010. Characterization of two NADPH: Cytochrome P450 reductases from cotton (Gossypium hirsutum). Phytochemistry 71: 27-35.

23. Li YY, Shen SD*, He LH, Xu P, Lu S. 2010. Sequence analysis of rDNA intergenic spacer (IGS) of Porphyra haitanensis. Journal of Applied Phycology 22: 187-193.

24. Chen L, Men X, Ma MR, Li PF*, Jiao QC, Lu S, Kong FX, Wu SC. 2009. Polysaccharide relase by Aphanothece halophytica inhibits cyanobacteria/clay flocculation. Journal of Phycology 46: 417-423.

25. Lu S, Li L*. 2008. Carotenoid metabolism: Biosynthesis, regulation, and beyond. Journal of Integrative Plant Biology 50: 778-785.

26. Zhou W, Zhu JY, Shen SD, Lu S, Wang JF, Xu JR, Xu P*. 2008. Observations on the division characterization of diploid nuclear in Porphyra (Bangiales, Rhodophyta). Journal of Applied Phycology 20: 991-999.

27. Guan XY, Yu N, Shangguan XX, Wang S, Lu S, Chen XY*. 2007. Arabidopsis trichome research sheds light on cotton fiber development mechanisms. Chinese Science Bulletin 52: 1734-1741.

28. Chen AX, Lou YG, Mao YB, Lu S, Wang LJ, Chen XY*. 2007. Plant terpenoids: Biosynthesis and ecoligical functions (Invited Review). Journal of Integrative Plant Biology 49: 179-186.

29. Lu S, Van Eck J, Zhou XJ, Lopez AB, O'Halloran DM, Cosman KM, Conlin BJ, Paolillo DJ, Garvin DF, Vrebalov J, Kochian LV, Kuepper H, Earle ED, Cao J, Li L*. 2006. The cauliflower Or gene encodes a cysteine-rich zinc finger domain-containing protein that mediates high-levels of beta-carotene accumulation. Plant Cell 18: 3594-3605.

30. Li* L, Lu S, Cosman KM, Earle ED, Garvin DF, O'Neill J. 2006. beta-carotene accumulation induced by the cauliflower Or gene is not due to an increased capacity of biosynthesis. Phytochemistry 67: 1177-1184

31. Li L*, Lu S, O'Halloran DM, Garvin DF, Vrebalov J. 2003. High-resolution genetic and physical mapping of the cauliflower high-beta-carotene gene Or (Orange). Molecular Genetics and Genomics 270: 132-138

32. Lu S, Xu R, Jia JW, Pang J, Matsuda SPT, Chen XY*. 2002. Cloning and functional characterization of a beta-pinene synthase from Artemisia annua that shows a circadian pattern of expression. Plant Physiology 130: 477-486

33. Zhou XJ, Lu S, Xu YH, Wang JW, Chen XY*. 2002. A cotton cDNA (GaPR-10) encoding a pathogenesis-related 10 protein with in vitro ribonuclease activity. Plant Science 162: 629-636

34. Yu XH, Zhu YQ, Lu S, Zhang TZ, Chen XY*, Xu ZH. 2000. A comparative analysis of a fuzzless-lintless mutant of Gosypium hirsutum L. cv. Xu-142. Science in China (Ser. C) 43: 623-630

35. Zhou XJ, Wang LS, Lin ZP, Jia JW, Lu S, Chu ZQ, Chen XY*. 2000. Fusion expression of Raphanus sativus- antifungal protein 1 (Rs-AFP1) in Escherichia coli and its antifungal activity on Verticillium dahliae. Acta Botanica Sinica 42: 703-707 

專著

1. Lu S. 2015. Plant Metabolic Network. In: Plant Metabolomics (Ed: Qi X-Q, Wang Y-L, Chen, X-Y). Springer. pp. 195-212.

2. Gantt E, Berg GM, Bhattacharya D, Blouin NA, Brodie JA, Chan CX, Collen J, Cunningham FXJr, Gross J, Grossman AR, Karpowicz S, Kitade Y, Klein AS, Levine IA, Lin SJ, Lu S, Lynch M, Minocha SC, Muller K, Neefus CD, De Oliveira MC, Rymarquis L, Smith A, Stiller JW, Wu WK, Yarish C, Zhuang YY, Brawley SH. 2010. Porphyra: complex life history in a harsh environment. P. umbilicalis, an intertidal red alga for genomic analysis. In Cellular Origin, Life in Extreme Habitats and Astrobiology. Vol. 13. Red Algae in the Genomic Age. (Sechbach J, Chapman DJ eds.). Springer. pp. 130-148.

3. Van Eck J, Zhou XJ, Lu S, Li L. 2009. Modulation of carotenoid accumulation in transgenic potato by inducing chromoplast formation with enhanced sink strength. In: Metabolic Enginnering of Plant Secondary Pathways (Ed.: Walker J). Humana Press. pp. 77-93.

4. 盧山，陳曉亞. 2012. 植物次生代謝。植物生理與分子生物學(xué)(第四版)(陳曉亞、薛紅衛(wèi)主編)。高等教育出版社. pp. 369-389

5. 盧山. 2011. 植物代謝網(wǎng)絡(luò)。植物代謝組學(xué)(漆小泉、王玉蘭、陳曉亞主編)。化學(xué)工業(yè)出版社. pp. 184-202

6. 陳曉亞，盧山. 2007. 植物次生代謝。植物生理與分子生物學(xué)(第三版)(陳曉亞、湯章城主編)。高等教育出版社. pp. 329-356

7. Lu S, Chen XY. 2005. Terpenoid metabolism in cotton and qiaohao (Artemisia annua). In: Advances in Plant Physiology (Ed.: Hemantaranjan A), Vol. 8. Pawan Kumar Scientific Publishers (India). pp. 265-292.

8. 費修綆, 王素娟, 盧山. 1998. 紅藻類細(xì)胞工程育種和育苗. 海洋生物技術(shù). 山東科技出版社. pp. 7-26. 

專利

1.盧山, 王彥文, 楊海燕. 一種擬南芥DnaJ-like蛋白及其編碼基因的應(yīng)用. 已授權(quán)(ZL201010180453.9)

2.Li Li, Shan Lu, David F. Garvin, Julia Vrebarov, Diana M. O’Halloran. Or gene and its use in manipulating carotenoid content and composition in plants and others organisms. US Patent (US 8,138,391 B1, Mar. 20, 2012).